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The article discusses a study from Gaffney and colleagues, published within the issue which provides evidence for the fundamental role that workplace transmission played in differences in the risk of COVID-19 infection. Topics include the impact of occupational transmission of COVID-19;reasons for the denial on the role of work in the risk of disease, injury and death;and means by which work as a fundamental determinant of health can be targeted.
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The article discusses how the coronavirus disease 2019 (COVID-19) pandemic affected keratoconus (KC) diagnosis and management. Topics explored include the delay in the delivery of ophthalmic care during the early days of the pandemic due to service suspensions, the visual acuity lost by patients due to the delayed KC diagnosis and treatment, and the necessity of in-person evaluation of patients for KC to ensure accuracy of diagnosis.
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The article presents the results of a qualitative study investigating the experiences of a sample of Italian adolescents during the COVID‐19 pandemic. Data were analysed in the light of the two social representations (adolescents as criminals and as victims) that permeated the Italian public debate throughout the outbreak. The findings showed the ability of boys and girls in dealing with the relationships altered by the pandemic constraints and in adapting to different regulations. This demonstrated their competence as social actors, neither criminals nor victims, who were also able to cope with the coronavirus risk in safeguarding their significant others.
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Background: The discovery of genotypes linked to geographic and temporal infectious clusters suggests that genotyping analysis can be used to track and monitor the transmission of corona virus. Objective: To explore the clinical value of causative agent for corona virus infection (CoVI) by using different genes (SARS-HCoV2 ORFlab JINZA1 and JINZA2 gene and HCoV NL63, HCoV OC43 and HCoV 229E in the diagnosis of causative agent for corona virus disease and severity of infection to know speed transmission this pandemic and control of disease. Patients and methods: Different types from human samples included nasal swabs, throat swabs and blood samples(plasma) from patients with CoVI and pneumonia. To diagnosis SARS-HCoV2 ORFlab JINZA1 and JINZA2 gene, and HCoV NL63 gene, HCoV OC43 gene and HCoV 229E gene. The positive ratio of SARS-HCoV2 ORFlab gene in the diagnosis of COVID-19 pneumonia confirmed by conventional PCR then gene sequencing by sanger method by using PCR product were sent for Sanger sequencing using ABI3730XL, automated DNA sequences, by Macrogen Corporation Korea. The results were received by email then analyzed using geneious software. Results: Assay for CoV the results shown P = 0.001 Highly sign. (P<0.01) within NL63 gene from nasal and throat swab positive n = 2 (10.53%) while negative n =17 (89.47 %) and P = 0.00 Highly sign. (P<0.01) within CT for NL63 gene positive n = 2 (4 %) while negative n = 48 (96 %). In addition to CoV result by PCR were P = 0.033 Sign. (P<0.05), positive n =17 (34%) and negative n =33 (66 %) from total n =50, and P = 0.019 Sign. (P<0.05) within SARSHCOV2 ORFlab gene from nasal swab by PCR positive n =4(21.05%), negative n = 15(78.95%) from total n =19 and P = 0.648 Non sign. (P>0.05) 229E gene from nasal and throat swab positive n =11(57.9%), negative n =8 (42.1%) from total n=19 (100%). While undetectable from OC43HCOV gene by real time PCR and by conventional PCR that indicated all results were negative for blood samples and from nasal and throat swab: Conclusion: Genotyping very important to know type of gene caused corona virus infection by using PCR real time PCR and conventional PCR indicated the study on the present other types of corona virus were HCOV 229E and NL63 HCOV and PCR product confirmed by Sanger sequencing using ABI3730XL, automated DNA sequences, the results concluded discovery two new isolates called SARSHCOV2ORF1ab JINZA1 gene and SARSHCOV2ORF1ab JINZA2 gene in Baghdad/Iraq patients and submitted in National Center for Biotechnology Information. SARSHCOV2ORF1ab JINZA1 OK486620 gene and JINZA2 OK586822 gene. The names of both genes according to name of PhD student Jnan Jafar Baksh, Supervisal Prof. Dr. Nazar Shiyaa Mohammed and Assist prof. Dr. Ahmed Saadi Hassan. BLAST results indicated because transmission by travel between Iraq and USA. Both of two patient's loss of their life due to severity of infection for JINZA1 and JINZA2 and were critical class for this pandemic.Recommendation: 1) Chosen specific primers for specific gene to avoid coinfection with other viruses and using confirmed tests include real time PCR or conventional PCR and gene sequencing for genotyping for corona virus to know speed viral transmission and control of disease: 2) Nasal swab and throat swab for detection from corona virus mostly greatest than blood samples because viral load higher and development molecular techniques and instruments for detection from virus when very low viral load.
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Background: Budesonide multimatrix is prescribed to treat forms of inflammatory bowel disease (IBD) during periods of relapse, and it is licensed to treat mild-to-moderate ulcerative colitis (UC). However, during the COVID-19 pandemic, there was a rise in the use of budesonide multimatrix to treat all forms of IBD after fears that systemic corticosteroid use, such as prednisolone, could increase the risk of COVID-19 severity. Methods: This audit included records of all patients who were prescribed the budesonide multimatrix Cortiment (9 mg once a day) over a year in NHS Lothian. Patients were grouped by disease activity at the point of prescription (Partial Mayo Score (PMS) less than 5 showed milder disease and above 5 showed more severe disease) and disease phenotype. The primary endpoint was response at 8 weeks from start of treatment, grouped into full response, partial response, no response and escalation. Results: The full response rate to budesonide multimatrix was 52% among all patients, but 80% in those with PMS ≤4 and only 15% in those with a PMS ≥5. By phenotype, response rates were 41% in Crohn's disease, 50% in IBD unclassified, 56% in proctitis, 56% in left-sided colitis and 51% in pancolitis. Conclusions: Budesonide multimatrix is effective to treat mild disease but is not effective in patients who are having a moderate-to-severe flare of IBD. This medication was 80% effective if the PMS was below 5, suggesting that it is very effective in mild disease.
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Purpose: This study assessed changes in speech-language pathology practice 1 year following the onset of the COVID-19 pandemic. The specific focus was on speech-language pathologists (SLPs) engaged in evaluation and treatment activities that pose an increased risk of virus transmission, namely, aerosol-generating procedures. Method: SLPs from the United States and Canada (n = 609) who were engaged in clinical activities with an elevated risk of COVID-19 exposure completed an online survey regarding their clinical practices. Topics assessed included continuation, modification, or cessation of clinical services, personal protective equipment (PPE) use, COVID-19 infections and vaccinations among SLPs, and financial impacts. For comparison, the results from the 2020 survey are included, and the percentage change (2020% - 2021%) is reported. Results: A majority of SLPs (90%) who completed the current survey reported that they were not experiencing PPE shortages, a marked change from the 2020 survey. Over half of the SLPs (52%) reported changes in clinical duties in 2021, with in-person visits and endoscopy being the most impacted. Nearly half of the respondents (49%) reported conducting virtual/telehealth clinical activities during the pandemic, and of these, 78% had not done any virtual/telehealth work prior to COVID-19. A positive COVID-19 test was reported by 10% of the SLPs (5% higher than in 2020). Most SLPs (92%) indicated they were vaccinated at the time of this survey. Conclusions: The 2021 survey data indicated an overall increase in SLP clinical activities compared with 2020 but have not yet returned to prepandemic levels. These results highlight a notable uptake of virtual/telehealth practice by SLPs, including those who had not previously done so. SLP vaccination rates also exceeded that of the general population.
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An introduction is presented in which the editor discusses articles in the issue on topics including treatment attenuates murine lupus;use of IFNα as a driver of variability in primary Sjögren's syndrome (SS);and immune-mediated inflammatory diseases (IMID) patients with B cell depletion therapy susceptible to breakthrough COVID-19.